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Prof. Dr.rer.nat. Agnes Nocon, Dipl.-Psych.

Professorin

LA 27-2.17

0991/3615-8852


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Zeitschriftenartikel

  • Agnes Nocon

Hilfesuchverhalten bei psychischen Problemen in Ostbayern

In: Beratung Aktuell (Junfermann Verlag) pg. 15-38.

  • (2021)
Eine mögliche Unterversorgung mit psychosozialen Hilfsangeboten in Ostbayern erschwert es Personen mit Hilfebedarf, angemessene Unterstützung zu erhalten. Die vorliegende Studie untersucht, welche Angebote Menschen in Ostbayern kennen, und wie sie nach professioneller Unterstützung im psychosozialen Bereich suchen. Befragt wur-den im Rahmen eines studentischen Forschungsprojektes 24 Erwachsene. In dieser Gruppe sind niederschwellige und kostenlose Angebote kaum bekannt, und Internetsuchmaschinen bestimmen die Suche nach Anlaufstellen, so dass davon ausgegangen werden kann, dass die Betroffenen keine transparenten Beurteilungsmöglichkeiten für die gefundenen Ergebnisse haben. Wenn die Versorgung im Bereich der psychischen Gesundheit verbessert werden soll, sollte eine bessere Ausstattung begleitet werden von Maßnahmen zur Erhöhung von Gesundheitskompetenz begleitet werden. Diese Aufgabe stellt sich potenziert in der Versorgung von Migrant:innen dar, bei denen Sprachbarrieren und fehlende soziale Netzwerke die Inanspruchnahme zusätzlich erschweren.
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Beitrag (Sammelband oder Tagungsband)

  • Agnes Nocon

Evaluating the ethical aspects of online counselling

In: Digitalization in Healthcare. Implementing Innovation and Artificial Intelligence (Future of Business and Finance)

[S.l.]

  • (2021)
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Zeitschriftenartikel

  • A. Vogel
  • H. Comtesse
  • Agnes Nocon
  • A. Kersting
  • W. Rief
  • R. Steil
  • R. Rosner

Feasibility of Present-Centered Therapy for Prolonged Grief Disorder: Results of a Pilot Study

In: Frontiers in Psychiatry (Section Mood and Anxiety Disorders) vol. 12 pg. 1-12.

  • (2021)

DOI: 10.3389/fpsyt.2021.534664

Present-centered therapy (PCT) was originally developed as a strong comparator for the non-specific effects of psychotherapy in the treatment of posttraumatic stress disorder. PCT qualifies as a not strictly supportive treatment as it is structured and homework is assigned between sessions. It does not focus on cognitive restructuring or exposure. A growing body of literature supports its beneficial effects. For example, it demonstrated only slightly inferior effect sizes and lower dropout rates compared to that of trauma-focused cognitive behavioral therapy in several trials with patients suffering from posttraumatic stress disorder. The current study is the first to evaluate the feasibility and the treatment effects of PCT in adults with prolonged grief disorder (PGD). Meta-analyses on psychotherapy for PGD have yielded moderate effect sizes. N = 20 individuals suffering from PGD were treated with PCT by novice therapists as part of a preparation phase for an upcoming RCT in an outpatient setting. Treatment consisted of 20–24 sessions á 50 min. All outcomes were assessed before treatment, at post-treatment, and at the 3-month follow-up. The primary outcome, PGD symptom severity, was assessed using the Interview for Prolonged Grief-13. Secondary outcomes were self-reported PGD severity, depression, general psychological distress, and somatic symptom severity. Furthermore, therapists evaluated their experiences with their first PCT patient and the treatment manual. In intent-to-treat analyses of all patients we found a significant decrease in interview-based PGD symptom severity at post-treatment (d = 1.26). Decreases were maintained up to the 3-month follow-up assessment (d = 1.25). There were also significant decreases in self-reported PGD symptoms, depression, and general psychological distress. No changes were observed for somatic symptoms. The completion rate was 85%. Therapists deemed PCT to be a learnable treatment program that can be adapted to the patient's individual needs. The preliminary results of PCT as a treatment for PGD demonstrate large effects and indicate good feasibility in outpatient settings. The treatment effects were larger than those reported in meta-analyses. Thus, PCT is a promising treatment for PGD. Possible future research directions are discussed.
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Vortrag

  • Agnes Nocon

Behandlungsmöglichkeiten bei Anhaltender Trauerstörung

In: Rotary Club Deggendorf

  • 7.12.2020 (2020)
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Vortrag

  • Agnes Nocon

Depression, Sucht, Anorexie und co. – Was tun bei psychischen Störungen?

In: Vortrag im Rahmen der Vortragsreihe Mensch und Gesundheit

Technische Hochschule Deggendorf Deggendorf

  • 09.10.2018 (2018)
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Zeitschriftenartikel

  • Agnes Nocon
  • R. Eberle-Sejari
  • J. Unterhitzenberger
  • R. Rosner

The effectiveness of psychosocial interventions in young war-traumatized refugees – systematic review and meta-analysis

In: European Journal of Psychotraumatology vol. 8 pg. 1388709.

  • (2017)

DOI: 10.1080/20008198.2017.1388709

Background: The United Nations reported that in 2016 over 65 million people worldwide have forcibly left home. Over 50% are children and adolescents; a substantial number has been traumatized and displaced by war. Objective: To provide an overview of the effectiveness of psychosocial interventions in this group we conducted a narrative review and a meta-analysis of intervention studies providing data on posttraumatic stress symptoms (PTSS), depression, anxiety, grief, and general distress. Method: We searched PILOTS, MEDLINE, WoS, Embase, CENTRAL, LILACS, PsycINFO, ASSIA, CSA, and SA for studies on treatment outcomes for war-traumatized displaced children and adolescents. Between-group effect sizes (ES) and pre-post ES were reconstructed for each trial. Overall pre-post ES were calculated using a random effects model. Results: The narrative review covers 23 studies with a variety of treatments. Out of the 35 calculated between-group ES, only six were significant, all compared to untreated controls. Two of them indicated significant adverse effects on symptoms of general distress or depression. When calculating pre-post effect sizes, the positive between-group results of cognitive behavioural therapy (CBT) and interpersonal therapy (IPT) were reproduced and singular other treatments showed significant positive effects. However, the mean pre-post effects for PTSS and depression could not be interpreted due to the high heterogeneity of the included studies (PTSS: ES = 0.78; I2 = 88.6%; depression: ES = 0.35; I2 = 93.1%). Only the mean pre-post effect for seven active CBT treatment groups for depression (ES = 0.30, 95% CI [0.18, 0.43]) was interpretable (Q = 3.3, df = 6, p = .77). Conclusion: Given the large number of children and adolescents displaced by war there were regrettably few treatment studies available, and many of them were of low methodological quality. The effect sizes lagged behind the effects observed in traumatized minors in general, and often were small or non-significant. However, CBT and IPT showed promising results that need further replication.
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Vortrag

  • Agnes Nocon

Psychische Gesundheit junger Flüchtlinge und Implikationen für die Freiwilligenarbeit

tun.starthilfe für Flüchtlinge Eichstätt

  • 24.05.2017 (2017)
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Vortrag

  • Agnes Nocon

Die Effektivität psychosozialer Interventionen bei kriegstraumatisierten jungen Flüchtlingen - systematisches Review und Metaanalyse

In: 19. Jahrestagung der Deutschsprachigen Gesellschaft für Psychotraumatologie (DeGPT) [09.-11.02.2017]

Zürich, Schweiz

  • 11.02.2017 (2017)
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Vortrag

  • Agnes Nocon

Trauma und Traumafolgestörungen

In: Informationsveranstaltung für ehrenamtliche Helfer "Seelische Belastungen durch Flucht und Trauma"

Landratsamt Eichstätt, Fachbereich Asyl, und Gemeindepsychiatrischer Verbund Eichstätt Eichstätt

  • 28.04.2016 (2016)
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Vortrag

  • Agnes Nocon

The effectiveness of psychosocial interventions in young war-traumatized refugees - systematic review and meta-analysis

In: ISTSS 32nd Annual Meeting (International Society for Traumatic Stress Studies) [November 10-12, 2016]

Dallas, TX, USA

  • 12.11.2016 (2016)
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Zeitschriftenartikel

  • R. Eberle-Sejari
  • Agnes Nocon
  • R. Rosner

Zur Wirksamkeit psychotherapeutischer Interventionen bei jungen Flüchtlingen und Binnenvertriebenen mit posttraumatischen Symptomen – ein systematischer Review

In: Kindheit und Entwicklung vol. 24 pg. 156-169.

  • (2015)

DOI: 10.1026/0942-5403/a000171

Trotz hoher Zahlen junger Flüchtlinge und der häufig hohen Belastung mit Symptomen einer Posttraumatischen Belastungsstörung (PTBS) gibt es Unsicherheiten über Therapiemöglichkeiten und deren Effektivität in dieser Patientengruppe. Zur Untersuchung der Wirksamkeit unterschiedlicher Interventionen wurde ein systematischer Review durchgeführt. Nach einer Literaturrecherche mit 798 Treffern erfüllten zehn Studien die Einschlusskriterien. Acht Studien konnten signifikante Reduktionen der PTBS-Symptomatik feststellen. Vielversprechend erscheinen dabei folgende Therapien: Narrative Expositionstherapie für Kinder, „Meditation-Relaxation”, Eye Movement Desensitization and Reprocessing und „Rapid-Ed-Therapie”. Aufgrund der dürftigen Studienlage und methodischer Mängel ist eine genauere Empfehlung allerdings schwierig.
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Zeitschriftenartikel

  • K. Fodor
  • J. Unterhitzenberger
  • C.-Y. Chou
  • D. Kartal
  • S. Leistner
  • M. Milosavljevic
  • Agnes Nocon
  • L. Soler
  • J. White
  • S. Yoo
  • E. Alisic

Is traumatic stress research global? A bibliometric analysis

In: European Journal of Psychotraumatology vol. 5 pg. 23269.

  • (2014)

DOI: 10.3402/ejpt.v5.23269

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Zeitschriftenartikel

  • Agnes Nocon
  • S. Jan
  • R. Rosner

Psychotherapeutic interventions from the western world in war-traumatized children - a metaanalysis . [Congress Abstract; 13th European Conference on Traumatic Stress: Trauma and its clinical pathways; PTSD and beyond; June 6-9, 2013, Bologna, Italy]

In: European Journal of Psychotraumatology vol. 55

  • (2013)
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Zeitschriftenartikel

  • S. Knappe
  • Agnes Nocon
  • K. Beesdo-Baum
  • H.-U. Wittchen

Further evidence for the differential familial aggregation of agoraphobia and panic disorder . [Congress Abstract; 102nd Annual American Psychopathological Association Meeting on “Multigenerational Transmission of Psychopathology"; March 1-3, 2012; New York, NY, USA]

In: Comprehensive Psychiatry vol. 54 pg. E5-E6.

  • (2013)
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Zeitschriftenartikel

  • R. Rosner
  • Agnes Nocon
  • M. Olff

Behandlung der posttraumatischen Belastungsstörung

In: PSYCH up2date vol. 7 pg. 301-315.

  • (2013)

DOI: 10.1055/s-0033-1349479

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Zeitschriftenartikel

  • S. Knappe
  • K. Beesdo-Baum
  • Agnes Nocon
  • H.-U. Wittchen

Re-examining the differential familial liability of agoraphobia and panic disorder

In: Depression and Anxiety vol. 29 pg. 931-938.

  • (2012)

DOI: 10.1002/da.21975

BACKGROUND: Controversy surrounds the question of whether agoraphobia (AG) exists as an independent diagnostic entity apart from panic. In favor of this position, AG without panic disorder (PD) in parents was found being unrelated to offsprings' risk for AG or PD, albeit it may enhance the familial transmission of PD (Nocon et al., Depress Anxiety 2008;25:422-434). However, a recent behavioral genetic analysis (Mosing et al., Depress Anxiety 2009;26:1004-1011) found an increased risk for both PD and AG in siblings of those with AG without PD, casting doubt on whether AG exists independently of PD. Convincing evidence for either position notably requires considering also other anxiety disorders to establish the position of AG relative to the panic/anxiety spectrum. METHODS: Familial transmission of panic attacks (PAs), PD, and AG was examined in a 10-year prospective-longitudinal community study of 3,021 adolescents and young adults including completed direct and indirect information on parental psychopathology. Standardized diagnostic assessments using the Munich-Composite International Diagnostic Interview allowed generating exclusive diagnostic groups independent from diagnostic hierarchy rules. RESULTS: Parental PD without AG was associated with an increased risk for PA and PD+AG, but not for PD without AG or AG without PD in offspring. Parental AG without PD was unrelated to the offsprings' risk for PA, exclusive PD or AG, or PD+AG. Findings were largely unaffected by adjustment for other offspring or parental anxiety disorders. CONCLUSIONS: Findings provide further evidence for the independence of AG apart from the PD spectrum.
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Zeitschriftenartikel

  • P. Zimmermann
  • T. Brückl
  • Agnes Nocon
  • A. Heck
  • H. Pfister
  • E. Binder
  • M. Uhr
  • R. Lieb
  • F. Holsboer
  • M. Ising

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: Results from a 10-year prospective community study

In: American Journal of Psychiatry vol. 168 pg. 1107-1116.

  • (2011)

DOI: 10.1176/appi.ajp.2011.10111577

Objective: The binding protein FKBP5 is an important modulator of the function of the glucocorticoid receptor, the main receptor of the stress hormone system. This turns the FKBP5 gene into a key candidate for gene-environment interactions, which are considered critical for pathogenesis of stress-related disorders. The authors explored gene-environment interactions between FKBP5 gene variants and adverse life events in predicting the first occurrence of a major depressive episode. Method: The analyses were based on 884 Caucasians in a 10-year prospective community study. At baseline, they were 14–24 years old and did not fulfill criteria for a major depressive episode. The DSM-IV-based Munich Composite International Diagnostic Interview was used to assess adverse life events preceding baseline and major depressive episodes during follow-up. On the basis of previous findings, five single-nucleotide polymorphisms (SNPs) within the FKBP5 gene were selected for genotyping. Results: While the authors did not observe genetic main effects, they found interactions between the five SNPs and traumatic (but not separation) events, with the strongest effect for severe trauma. The effect of trauma on incident major depressive episodes was evident among subjects homozygous for the minor alleles but not subjects with other genotypes. The findings were replicated in the U.K. Environmental Risk Longitudinal Twin Study. Conclusions: These hypothesis-driven results suggest that an interaction between FKBP5 genotype and trauma is involved in the onset of depression. Subjects homozygous for the minor alleles of the investigated FKBP5 SNPs seem to be particularly sensitive to effects of trauma exposure in terms of triggering depression onset.
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Beitrag (Sammelband oder Tagungsband)

  • Agnes Nocon
  • H. Pfister
  • M. Rosenhagen
  • S. Lucae
  • M. Uhr
  • M. Ising

The combined effects of cognitive behavior therapy and pharmacotherapy on emotion-regulation in depressed patients

München

  • (2010)
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Hochschulschrift

  • Agnes Nocon

Die Stellung der Agoraphobie in modernen diagnostischen Klassifikationssystemen: Beitrag zu einer nosologischen Kontroverse

Technische Universität Dresden Dresden Institut für Klinische Psychologie und Psychotherapie (Fachrichtung Psychologie)

  • 2010 (2010)

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Zeitschriftenartikel

  • P. Zimmermann
  • T. Brückl
  • Agnes Nocon
  • H. Pfister
  • R. Lieb
  • H.-U. Wittchen
  • F. Holsboer
  • J. Angst

Heterogeneity of DSM-IV Major Depressive Disorder as a Consequence of Subthreshold Bipolarity

In: Archives of General Psychiatry vol. 66 pg. 1341-1352.

  • (2009)
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Vortrag

  • Agnes Nocon

Die Rolle der Genetik bei Angst- und Zwangsstörungen

In: Jahrestagung "Obsessionen, Zwänge, Tics, Verhaltenssüchte...?" der Deutschen Gesellschaft Zwangserkrankungen (DGZ) und der Tourette-Gesellschaft Deutschland (TGD)

München

  • 16.10.2009 (2009)
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Beitrag (Sammelband oder Tagungsband)

  • Agnes Nocon
  • K. Hackmann
  • H. Pfister
  • B. Heldmann
  • M. Rosenhagen
  • S. Lucae
  • M. Ising

Biomarkers for the efficacy of cognitive behavioral therapy in antidepressant treatment in depression

München

  • (2009)
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Zeitschriftenartikel

  • P. Zimmermann
  • T. Brückl
  • H. Pfister
  • R. Lieb
  • H.-U. Wittchen
  • F. Holsboer
  • M. Ising
  • E. Binder
  • M. Uhr
  • Agnes Nocon

The interplay of variations in the FKBP5 gene and adverse life events in predicting the first onset of depression during a ten-year follow-up . [Congress Abstract; 26th Symposium of the AGNP; Munich; October, 7-10, 2009]

In: Pharmacopsychiatry vol. 42 pg. A189.

  • (2009)
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Zeitschriftenartikel

  • Agnes Nocon
  • K. Hackmann
  • H. Pfister
  • B. Heldmann
  • M. Rosenhagen
  • S. Lucae
  • M. Ising

Biomarkers for the combined efficacy of cognitive behavioural therapy in antidepressant treatment in depression . [Abstract]

In: European Neuropsychopharmacology vol. 19 pg. S427.

  • (2009)
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Zeitschriftenartikel

  • Agnes Nocon
  • K. Hackmann
  • H. Pfister
  • B. Heldmann
  • S. Lucae
  • M. Rosenhagen
  • M. Ising

Biomarkers for the combined efficacy of cognitive behavioral therapy in antidepressant treatment in depression . [Congress Abstract; 26th Symposium of the AGNP]

In: Pharmacopsychiatry vol. 42 pg. A114.

  • (2009)
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Beitrag (Sammelband oder Tagungsband)

  • Agnes Nocon
  • T. Brückl
  • P. Zimmermann
  • H. Pfister
  • M. Höfler
  • R. Lieb
  • H.-U. Wittchen
  • M. Ising

Pathways into panic and phobias

München

  • (2008)
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Zeitschriftenartikel

  • P. Zimmermann
  • T. Brückl
  • R. Lieb
  • Agnes Nocon
  • M. Ising
  • K. Beesdo
  • H.-U. Wittchen

The interplay of familial depression liability and adverse events in predicting the first onset of depression during a 10-year follow-up

In: Biological Psychiatry vol. 63 pg. 406-414.

  • (2008)

DOI: 10.1016/j.biopsych.2007.05.020

BACKGROUND: The aim of the present article is to explore interaction and correlation effects between familial depression liability and selected adverse (separation and traumatic) events in predicting the first onset of a major depressive episode (MDE) in a 10-year prospective longitudinal community survey. METHODS: Analyses are based on 1982 subjects (14 to 24 years at baseline) without baseline MDE who participated during the whole study period and for whom diagnostic information about psychopathology in both parents was available. The offspring's familial depression liability was determined by aggregating information on parental depressive symptoms obtained from family history data and direct interviews with parents. Data were assessed with the Munich-Composite International Diagnostic Interview according to its DSM-IV algorithms. RESULTS: Adverse events predicted a substantially increased incidence of MDE among respondents with familial liability but not in those without familial liability. There was a significant interaction between familial liability and traumatic events with the strongest effect for the number of severe traumatic events (risk difference = 11.3%; 95% confidence interval = 3.55-19.15). Associations with familial liability were most pronounced for separation events. CONCLUSIONS: Adverse events are particularly pathogenic in individuals with familial liability. The involvement of interactions and correlations between familial liability and adversity might depend on type, severity, and number of events. Both processes are suggested to be concomitant rather than exclusive.
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Zeitschriftenartikel

  • H.-U. Wittchen
  • Agnes Nocon
  • K. Beesdo
  • D. Pine
  • M. Hoefler
  • R. Lieb
  • A. Gloster

Agoraphobia and Panic: Prospective-longitudinal Relations Suggest a Rethinking of Diagnostic Concepts

In: Psychotherapy and Psychosomatics vol. 77 pg. 147-157.

  • (2008)

DOI: 10.1159/000116608

Background: The relationship of panic attacks (PA), panic disorder (PD) and agoraphobia (AG) is controversial. The aim of the current study is to prospectively examine the 10-year natural course of PA, PD and AG in the first three decades of life, their stability and their reciprocal transitions. Methods: DSM-IV syndromes were assessed via Composite International Diagnostic Interview – Munich version in a 10-year prospective-longitudinal community study of 3,021 subjects aged 14–24 years at baseline. Results: (1) Incidence patterns for PA (9.4%), PD (with and without AG: 3.4%) and AG (5.3%) revealed differences in age of onset, incidence risk and gender differentiation. (2) Temporally primary PA and PD revealed only a moderately increased risk for subsequent onset of AG, and primary AG had an even lower risk for subsequent PA and PD. (3) In strictly prospective analyses, all baseline groups (PA, PD, AG) had low remission rates (0–23%). Baseline PD with AG or AG with PA were more likely to have follow-up AG, PA and other anxiety disorders and more frequent complications (impairment, disability, help-seeking, comorbidity) as compared to PD without AG and AG without PA. Conclusions: Differences in incidence patterns, syndrome progression and outcome, and syndrome stability over time indicate that AG exists as a clinically significant phobic condition independent of PD. The majority of agoraphobic subjects in this community sample never experienced PA, calling into question the current pathogenic assumptions underlying the classification of AG as merely a consequence of panic. The findings point to the necessity of rethinking diagnostic concepts and DSM diagnostic hierarchies.
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Zeitschriftenartikel

  • Agnes Nocon
  • T. Brückl
  • P. Zimmermann
  • J. Rehm
  • H. Irving
  • H. Pfister
  • M. Höfler
  • R. Lieb
  • H.-U. Wittchen

Pathways into panic and phobias . [Abstract]

In: The International Journal of Neuropsychopharmacology vol. 11 pg. 284.

  • (2008)
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Zeitschriftenartikel

  • Agnes Nocon
  • H.-U. Wittchen
  • K. Beesdo
  • D. Pine
  • M. Höfler
  • R. Lieb
  • A. Gloster

Relationship of panic and agoraphobia: rethinking of a diagnostic concept? . [Abstract]

In: European Neuropsychopharmacology vol. 18 pg. S491-S492.

  • (2008)
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Zeitschriftenartikel

  • Agnes Nocon
  • H.-U. Wittchen
  • K. Beesdo
  • T. Brückl
  • M. Höfler
  • M. Pfister
  • P. Zimmermann
  • R. Lieb

Differential familial liability of panic disorder and agoraphobia

In: Depression and Anxiety vol. 25 pg. 422-434.

  • (2008)

DOI: 10.1002/da.20425

To examine the familial liability of panic disorder (PD) and agoraphobia (AG) in a community sample, namely the effect of parental PD and AG on the offspring's risk to develop either or both conditions in adolescence or adulthood. A representative community sample of N=3,021 adolescents and young adults aged 14-24 years at baseline was followed up over a period of 10 years in up to four waves. Family information was assessed by either direct interviews with at least one parent or by using subjects' family history information at either wave (N=3,014). Diagnoses and selected symptoms were assessed in both, parents and subjects, by using a standardized diagnostic interview (DSM-IV M-CIDI) with its respective family history module. (1) Parental panic attacks (PA), PD, and AG were all shown to be associated with an increased risk of offspring to also develop PA, PD, and AG. (2) Associations of parental PD were present irrespective of parental AG, whereas parental AG without PD was not associated with an increased offspring risk. (3) Outcome risk was particularly elevated in offspring of parents with PD+AG. (4) Parental PD or AG was not associated with an earlier age of onset of any syndrome in the offspring. We confirmed and expanded previous results from clinical samples that comorbid PD and AG aggregate in families. AG without PD is not familial, but it might enhance the familial transmission of PD.
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Zeitschriftenartikel

  • T. Brückl
  • P. Zimmermann
  • Agnes Nocon
  • H.-U. Wittchen
  • R. Lieb
  • M. Ising

Birth complications increase the liability for depression according to trauma . [Abstract]

In: Nervenarzt vol. 78 pg. 185.

  • (2007)
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Zeitschriftenartikel

  • Agnes Nocon
  • D. Bergé
  • M. Astals
  • R. Martin-Santos
  • M. Torrens

Psychiatric comorbidity in drug abusers admitted for detoxification: prevalence and implications

In: European Addiction Research vol. 13 pg. 192-200.

  • (2007)
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Zeitschriftenartikel

  • Agnes Nocon
  • T. Brückl
  • P. Zimmermann
  • R. Lieb
  • H.-U. Wittchen

Specific vulnerability and risk factors for the onset of panic disorder, agoraphobia and other phobias . [Congress Abstract; 25th Symposium of the AGNP; Munich; October, 3-6, 2007]

In: Pharmacopsychiatry vol. 40 pg. 232.

  • (2007)
Background: On the background of the ongoing debate whether agoraphobia is a conditioned reaction to biologically elicited panic attacks as proposed by Donald Klein, or whether agoraphobia is accompanied by panic attacks just like other phobias as suggested by Isaac Marks, we aim to study the common and the specific nature of vulnerability/risk factors of panic disorder [PD], agoraphobia [AG], social [SOC] and specific phobia [SPE]. Method: Analyses are based on 3021 participants from a 10-year prospective-longitudinal community survey (14-24 years old at baseline). Lifetime DSM-IV diagnoses and syndromes were assessed via standardized M-CIDI interview. Vulnerabilities in three domains (socio-demographic, family and behavioral-emotional) were assessed. Results: (1) Subjects with PD, SOC and SP were at higher risk for AG, and subjects with AG and SP were at higher risk for panic attacks/disorder. 2) All syndromes were associated with behavioral inhibition (fear). 3) Only phobias, but not PD, were associated with temperament (harm avoidance), behavioral inhibition (social), gender, parental mood disorder, and separation from parents. 4) Parenting style (rejection) was associated to SOC and SP, but not to AG or PD. Discussion: There is some evidence that phobias (particularly AG and SP) are similar with respect to anxiety comorbidity patterns and associations with socio-demographic, family and behavioral-emotional factors, and that these associations are not accounted for by anxiety comorbidity. Risk factors for PD might be rather unspecific and accounted for by comorbid phobias.
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Buch (Monographie)

  • Agnes Nocon

Angst und Depression bei Jugendlichen. Häufigkeit, Komorbiditätsmuster und zeitlicher Verlauf. .

VDM Verlag Dr. Müller Saarbrücken

  • (2007)
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Beitrag (Sammelband oder Tagungsband)

  • Agnes Nocon
  • H.-U. Wittchen
  • K. Beesdo
  • T. Brückl
  • M. Hofler
  • H. Pfister
  • P. Zimmermann
  • R. Lieb
  • M. Ising

Differential familial liability of panic disorder and agoraphobia

München

  • (2007)
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Beitrag (Sammelband oder Tagungsband)

  • T. Brückl
  • P. Zimmermann
  • Agnes Nocon
  • H.-U. Wittchen
  • R. Lieb
  • M. Ising

Exposure to natal complications influences vulnerability for depression under traumatic conditions

München

  • (2007)
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Vortrag

  • Agnes Nocon

Agoraphobia and panic: rethinking of diagnostic concepts

In: Winter Seminar in Affective Neuroscience (26.02.-02.03.2007)

Bristol University Bristol, UK

  • 01.03.2007 (2007)
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Vortrag

  • Agnes Nocon

Panic disorder and agoraphobia: are they distinct entities?

In: Institutsseminar des Max-Planck-Instituts für Psychiatrie

München

  • 18.01.2007 (2007)
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Beitrag (Sammelband oder Tagungsband)

  • Agnes Nocon
  • H.-U. Wittchen
  • H. Pfister
  • M. Höfler
  • R. Lieb

Eltern mit Panik und ihre Kinder . [Abstract]

Lengerich; Berlin; Bremen; Miami; Riga; Viernheim; Wien; Zagreb

  • (2006)
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Zeitschriftenartikel

  • Agnes Nocon
  • H.-U. Wittchen
  • H. Pfister
  • P. Zimmermann
  • R. Lieb

Dependence symptoms in young cannabis users? A prospective epidemiological study

In: Journal of Psychiatric Research vol. 40 pg. 394-403.

  • (2006)

DOI: 10.1016/j.jpsychires.2005.07.011

AIM: To examine prospectively over a period of 4 years the profile of cannabis dependence and the risk of specific dependence criteria in a community sample of adolescents. METHODS: A representative community sample of 2446 young adults aged 14-24 years at baseline was followed up over a period of 4 years. Frequency of use measures and of criteria for DSM-IV dependence were assessed by standardized diagnostic interview measures (CIDI). To explore the nature of this association, frequency of use and concomitant use of other psychoactive substances was considered. RESULTS: 30% of the sample were cannabis users. Among all users 35% met at least one dependence criterion. Most frequently reported dependence criteria among all users were withdrawal (17%), tolerance (15%), loss of control (14%) and continued use despite a health problem (13%). Even without concomitant use of other illicit drugs, 22% of low frequency users and 81% of high frequency users met at least one dependence criterion. Symptom patterns were similar in high and low frequency users. The occurrence of a dependence syndrome or of specific dependence criteria could not be attributed to the use of other illicit drugs or to comorbid nicotine and alcohol dependence. CONCLUSIONS: Regular cannabis use in adolescence is associated with the development of a dependence syndrome. This association cannot be explained by the concomitant use of other illicit substances or by comorbid nicotine and alcohol dependence.
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Zeitschriftenartikel

  • H.-U. Wittchen
  • P. Zimmermann
  • F. Waszak
  • Agnes Nocon
  • M. Höfler
  • R. Lieb

Pathways into ecstasy use: the role of prior cannabis use and ecstasy availability (P.6.c.007) . Abstract

In: European Neuropsychopharmacology vol. 16 pg. S504.

  • (2006)

DOI: 10.1016/S0924-977X(06)70686-1

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Zeitschriftenartikel

  • R. Lieb
  • L. Schwender
  • Agnes Nocon
  • H. Pfister
  • H.-U. Wittchen

Natural course of obsessive compulsive disorder (OCD) over four years: findings from a prospective community study of adolescents and young adults (P.4.a.007) . Abstract

In: European Neuropsychopharmacology vol. 16 pg. S451-S452.

  • (2006)

DOI: 10.1016/S0924-977X(06)70588-0

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Vortrag

  • Agnes Nocon

Die familiäre Übertragung von Panik und Agoraphobie: Beitrag zu einer alten Kontroverse

In: Forschungskolloquium der Klinischen Psychologie

Technische Universität Dresden Dresden

  • 25.10.2006 (2006)
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Beitrag (Sammelband oder Tagungsband)

  • Agnes Nocon
  • H.-U. Wittchen
  • H. Pfister
  • M. Höfler
  • R. Lieb
  • M. Ising

Panic and agoraphobia in the first three decades of life

München

  • (2006)
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Zeitschriftenartikel

  • R. Lieb
  • L. Schwender
  • Agnes Nocon
  • H. Pfister
  • H.-U. Wittchen

The natural course of obsessive compulsive disorder over four years: Findings from a prospective community study of adolescents and young adults . [Abstract; Poster Session at the 8th ECNP Regional Meeting, Moscow, Russia; June 14-15, 2005]

In: European Neuropsychopharmacology vol. 15 pg. S165.

  • (2005)

DOI: 10.1016/S0924-977X(05)80342-6

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Beitrag (Sammelband oder Tagungsband)

  • Agnes Nocon
  • L. Schwender
  • M. Höfler
  • H.-U. Wittchen
  • R. Lieb

Panic in parents – panic in children?

München

  • (2005)
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Beitrag (Sammelband oder Tagungsband)

  • Agnes Nocon
  • L. Schwender
  • M. Höfler
  • H.-U. Wittchen
  • R. Lieb

Panische Eltern – Panische Kinder? . [Abstract]

Lengerich

  • (2005)
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Zeitschriftenartikel

  • P. Zimmermann
  • H.-U. Wittchen
  • F. Waszak
  • M. Höfler
  • Agnes Nocon
  • R. Lieb

Pathways into ecstasy use: Impact of cannabis on availability and first use of ecstasy

In: Drug and Alcohol Dependence vol. 79 pg. 331-341.

  • (2005)

DOI: 10.1016/j.drugalcdep.2005.02.008

AIM: To explore the role of cannabis use for the availability of ecstasy as a potential pathway to subsequent first ecstasy use. METHODS: Baseline and 4-year follow-up data from a prospective-longitudinal community study of originally 3021 adolescents and young adults aged 14-24 years at baseline were assessed using the standardized M-CIDI and DSM-IV criteria. RESULTS: Baseline cannabis users reported at follow-up more frequent access to ecstasy than cannabis non-users. Higher cannabis use frequencies were associated with increased ecstasy availability reports. Logistic regression analyses revealed that cannabis use and availability of ecstasy at baseline are predictors for incident ecstasy use during the follow-up period. Testing simultaneously the impact of prior cannabis use and ecstasy availability including potential confounders, the association with cannabis use and later ecstasy use was confirmed (OR=6.3; 95%CI=3.6-10.9). However, the association with ecstasy availability was no longer significant (OR=1.2; 95%CI=0.3-3.9). CONCLUSIONS: Results suggest that cannabis use is a powerful risk factor for subsequent first onset of ecstasy use and this relation cannot be sufficiently explained by availability of ecstasy in the observation period.
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Zeitschriftenartikel

  • D. Bergé
  • F. Fonseca
  • G. Mateu
  • Agnes Nocon
  • M. Torrens

Edad de inicio en el consumo de sustancias y gravedad clínica de la drogodependencia [Age of onset of substance use and clinical severity]

In: Revista de Psiquiatría de la Facultad de Medicina de Barcelona vol. 32 pg. 166-172.

  • (2005)
The aim of this study is to confirm the hypothesis of more psychiatric and somatic (HIV, HCV) comorbidity, more psycho-social severity and worst global functioning in patients with early-onset of illicit substance use (before 18 years old), in an inpatient detoxification unit. All ca- ses admitted to a detoxification unit during a 20 years study period (n=2883) were studied prospectively, comparing those patients with an onset of substance use before 18 years old (early-onset) with the rest of the patients, considering socio-demographic and substance use characteristics, psychiatric comorbidity, somatic complications (HCV, HIV), psycho-social severity and glo- bal functioning and outcome characteristics. Early-onset substance users (EOSU) had more number of substance use disorders, more frequently presented opioids, cannabis and sedatives related disorders and presented more Axis II comorbidity, concretely antisocial and borderline PD diagnostics. EOSU had also more HIV and HCV infection, more previous overdoses, more arrests and imprisonments, a lower score in GAF Scale, and were more frequently unemployed in comparison to late- onset substance users.
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Zeitschriftenartikel

  • A. Perkonigg
  • H.-U. Wittchen
  • P. Zimmermann
  • Agnes Nocon
  • A. Settele
  • B. Spiegel
  • G. Bühringer
  • R. Lieb

Grundlagen und Forschungsstrategien regionaler Bedarfs- und Allokationsprozesse am Beispiel des ASAT-F1-Projektes

In: Suchtmedizin vol. 6 pg. 14-21.

  • (2004)
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Beitrag (Sammelband oder Tagungsband)

  • Agnes Nocon
  • H.-U. Wittchen

Kann man von Cannabis eigentlich abhängig werden? . [Abstract]

Lengerich; Berlin; Bremen; Miami; Riga; Viernheim; Wien; Zagreb

  • (2004)
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Vortrag

  • Agnes Nocon

Kann man von Cannabis eigentlich abhängig werden?

In: 22. Symposium Klinische Psychologie und Psychotherapie, Fachgruppe Klinische Psychologie und Psychotherapie der DGPs

Halle/Saale

  • 20.05.2004 (2004)
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Vortrag

  • Agnes Nocon

Relationships among anxiety disorders: Patterns and implications

In: Forschungskolloquium des Institut Municipal d'Investigació Mèdica

Barcelona, Spanien

  • 21.03.2003 (2003)
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Beitrag (Sammelband oder Tagungsband)

  • H.-U. Wittchen
  • Y. Lecrubier
  • K. Beesdo
  • Agnes Nocon

Relationships among anxiety disorders: Patterns and implications

pg. 25-37.

Oxford

  • (2003)
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